The fermentation process is one of the major cost drivers in industrial production. The fermentation processes developed at ARTES are based on low-cost, fully synthetic media avoiding expensive additives (e.g. methanol or IPTG) and aiming at short production times (approx. 45 – 75 hrs. for yeast; approx. 24 hrs. for E. coli). High productivity obtained with ARTES´ technologies directly translates into savings in energy, investment, consumables and waste.

Up- and downstream process development is designed right from the start to meet cGMP and large scale requirements in later-on routine manufacturing. Special emphasis is given on reproducibility and cost reduction. In-process control and final characterization of the product and of host/process related impurities are included in our process development. If applicable, this characterization is performed according to international pharmacopoeia.

ARTES provides to the client the full set of documentation necessary to transfer the process to his manufacturing site or to a CMO. Product samples generated and arms-length assistance in the transfer of the process developed are added to our offer.

cGMP compliant method development and routine analyses can be contracted with ARTES as well and will be provided in close collaboration with our industrial partners.

Large scale manufacturing (nonGMP and cGMP) can be contracted as well and will be performed at ARTES or at our partner facilities.

ARTES´ offer includes:

  • fermentation process development
  • downstream process development
  • in-process and quality control assay development