The fer­men­tation process is one of the major cost dri­vers in indus­tri­al pro­duc­tion. The fer­men­ta­tion process­es devel­oped at ARTES are based on low-cost, ful­ly syn­thet­ic media avoid­ing expen­sive addi­tives (e.g. methanol or IPTG) and aim­ing at short pro­duc­tion times (approx. 45 – 75 hrs. for yeast; approx. 24 hrs. for E. coli). High pro­duc­tiv­i­ty obtained with ARTES´ tech­nolo­gies direct­ly trans­lates into sav­ings in ener­gy, invest­ment, con­sum­ables and waste.

Up- and down­stream process devel­op­ment is designed right from the start to meet cGMP and large scale require­ments in lat­er-on rou­tine man­u­fac­tur­ing. Spe­cial empha­sis is giv­en on repro­ducibil­i­ty and cost reduc­tion. In-process con­trol and final char­ac­ter­i­za­tion of the prod­uct and of host/process relat­ed impu­ri­ties are includ­ed in our process devel­op­ment. If applic­a­ble, this char­ac­ter­i­za­tion is per­formed accord­ing to inter­na­tion­al pharmacopoeia.

ARTES pro­vides to the client the full set of doc­u­men­ta­tion nec­es­sary to trans­fer the process to his man­u­fac­tur­ing site or to a CMO. Prod­uct sam­ples gen­er­at­ed and arms-length assis­tance in the trans­fer of the process devel­oped are added to our offer.

cGMP com­pli­ant method devel­op­ment and rou­tine analy­ses can be con­tract­ed with ARTES as well and will be pro­vid­ed in close col­lab­o­ra­tion with our indus­tri­al partners.

Large scale man­u­fac­tur­ing (nonGMP and cGMP) can be con­tract­ed as well and will be per­formed at ARTES or at our part­ner facilities.

ARTES´ offer includes:

  • fer­men­ta­tion process development
  • down­stream process development
  • in-process and qual­i­ty con­trol assay development