ARTES uses one of the most important industrial expression systems, the methylotrophic yeast Hansenula polymorpha (syn. Pichia angusta). For our platform technology, we have all relevant IP rights as well as unpatent know-how. Our expertise is on trouble-shooting and project management. ARTES ensures 100% freedom-to-operate for all clients and licensees and guarantees a smooth and high standard project progress.

Features of Hansenula technology platform:

  • large toolbox (e.g. expression vectors, secretion signals, chaperones)
  • stable co-expression of multiple genes
  • high copy production cell lines with up to 120 genes per cell
  • 100% stability of production cell lines for so far > 25 years
  • absence of allergens, toxins and viral contaminations
  • secreted products without contaminating host cell proteins (> 90% purity in fermentation broth)
  • high yield production of intra-cellular soluble proteins
  • metabolic engineering for design of whole-cell biocatalysts
  • organism known at and recommended by a.o. US-FDA, EMA, EFSA and WHO
  • antibiotic resistance free host vector system