For the expres­sion of a recom­bi­nant pro­tein in a bac­te­r­i­al sys­tem, ARTES pro­vides a high­ly effi­cient E. coli plat­form. The plat­form is char­ac­ter­ized with a host/vector tool­box for opti­mal expres­sion and with the abil­i­ty to release recom­bi­nant pro­teins into the cul­ture supernatant.

Because of the releas­ing fea­ture, the iden­ti­fi­ca­tion and purifi­ca­tion of the recom­bi­nant pro­tein after fer­men­ta­tion is much eas­i­er than in a nor­mal E. coli fer­men­ta­tion process. After fer­men­ta­tion, the pro­tein will be found in the super­natant of the broth. For the purifi­ca­tion process, steps as cell dis­rup­tion or fold­ing and refold­ing will not be nec­es­sary any more. The secre­tion prop­er­ty of our E. coli sys­tem flows direct­ly into the effi­cien­cy of pro­duc­tion costs for the man­u­fac­tur­ing of the recom­bi­nant prod­uct of our client.