Enzymes

Feed/Food – Detergents – Fine Chemicals

Industrial enzymes require large scale manufacturing processes with low cost-of-goods.

In addition, sustainability is of prime interest in modern manufacturing.

ARTES´ technology platform realizes m³ scales at extremely reduced manufacturing costs due to growth and enzyme production in fully synthetic media supplemented with nitrogen and carbon sources derived from industrial waste streams (bio-diesel waste, molasse, rape seed extract) and void of cost-driving or animal derived components. Sustainability and cost saving are ideally combined in our innovative solutions!

In accordance with the regulation No. 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition, ARTES applies an antibiotic-resistance free technology platform for production of GRAS confirmed feed and food enzymes.

Veterinary

Vaccines – Therapeutics – Anti Microbial Peptides

According to the US FDA, antimicrobial resistance is recognized as a growing global threat. Via horizontal gene transfer, antibiotic resistance genes may be transferred to humans, thereby reducing the effectiveness of antimicrobial drugs for treating human disease.

ARTES´ provides access to its proprietary yeast technology platform completely void of any antibiotic resistance marker throughout the full manufacturing process of veterinary products, such as vaccines, therapeutic proteins and anti microbial peptides. Together with allergen and toxin free production cell lines, ARTES ensures safe veterinary products.

The METAVAX® technology platform is ideally suited for development of veterinary vaccines by presentation of target antigens in form of chimeric virus like particles (VLPs).

Cosmetics

DNA Repair Enzymes – Anti-microbial Peptides – Stabilizer

DNA repair enzymes and growth factors are active components in today´s innovative skin care cosmetics. Anti-microbial peptides and innovative stabilizer serve as alternatives to commonly used preservatives which may cause irritations or allergenic reactions.

Production processes applied for manufacturing of these new class of cosmetic ingredients need to address first of all safety issues. At the same time, high volume production at considerably reduced manufacturing costs is a prerequisite for successful market introduction.

ARTES´ Hansenula yeast technology provides an excellent platform for large-scale, low-cost production of cosmetic ingredients. Non-allergenic and endotoxin free production cell lines together with an antibiotic-resistance free vector system form the basis for self-affirmed GRAS products and safe cosmetic ingredients introduced in the market.

Biocatalysts

Pharmaceuticals – Flavours – Fragrances – Cosmetic Ingredients – Fine Chemicals

Whole-cell catalysts can act as highly specific, reusable tools in the manufacture of various fine chemicals, pharmaceuticals, fragrances and cosmetic ingredients. Conversion of low cost substrate into high value product can be realized in highly sustainable processes. While chemical reactions generally result in consequences such as production of waste streams containing various toxic acids and heavy metals and generation of undesired by-products, innovative processes involving yeast based whole-cell biocatalysts generate pure product at high efficiency and without unwanted, hazardous waste.

With ARTES´ yeast technology complex biosynthetic pathways can be stably implemented and reusable biocatalysts can be manufactured at large scale and low costs.



Examples of Hansenula based biocatalytic conversions:

  • production of enantiomeric pure alcohols (1-S-phenylethanol, …
  • production of pyruvic acid and glyoxylic acid
  • production of Ectoin resp. Hydroxy-Ectoin as substances in cosmetics
  • production of cell-wall anchored enzymes; e.g. Candida antarctica Lipase B (CalB)