Enzymes

Feed/Food – Deter­gents – Fine Chemicals

Indus­tri­al enzymes require large scale man­u­fac­tur­ing process­es with low cost-of-goods.

In addi­tion, sus­tain­abil­i­ty is of prime inter­est in mod­ern manufacturing.

ARTES´ tech­nol­o­gy plat­form real­izes m³ scales at extreme­ly reduced man­u­fac­tur­ing costs due to growth and enzyme pro­duc­tion in ful­ly syn­thet­ic media sup­ple­ment­ed with nitro­gen and car­bon sources derived from indus­tri­al waste streams (bio-diesel waste, molasse, rape seed extract) and void of cost-dri­ving or ani­mal derived com­po­nents. Sus­tain­abil­i­ty and cost sav­ing are ide­al­ly com­bined in our inno­v­a­tive solutions!

In accor­dance with the reg­u­la­tion No. 1831/2003 of the Euro­pean Par­lia­ment and of the Coun­cil of 22 Sep­tem­ber 2003 on addi­tives for use in ani­mal nutri­tion, ARTES applies an antibi­ot­ic-resis­tance free tech­nol­o­gy plat­form for pro­duc­tion of GRAS con­firmed feed and food enzymes.

Veterinary

Vac­cines – Ther­a­peu­tics – Anti Micro­bial Peptides

Accord­ing to the US FDA, antimi­cro­bial resis­tance is rec­og­nized as a grow­ing glob­al threat. Via hor­i­zon­tal gene trans­fer, antibi­ot­ic resis­tance genes may be trans­ferred to humans, there­by reduc­ing the effec­tive­ness of antimi­cro­bial drugs for treat­ing human disease.

ARTES´ pro­vides access to its pro­pri­etary yeast tech­nol­o­gy plat­form com­plete­ly void of any antibi­ot­ic resis­tance mark­er through­out the full man­u­fac­tur­ing process of vet­eri­nary prod­ucts, such as vac­cines, ther­a­peu­tic pro­teins and anti micro­bial pep­tides. Togeth­er with aller­gen and tox­in free pro­duc­tion cell lines, ARTES ensures safe vet­eri­nary products.

The METAVAX® tech­nol­o­gy plat­form is ide­al­ly suit­ed for devel­op­ment of vet­eri­nary vac­cines by pre­sen­ta­tion of tar­get anti­gens in form of chimeric virus like par­ti­cles (VLPs).

Cosmetics

DNA Repair Enzymes – Anti-micro­bial Pep­tides — Stabilizer

DNA repair enzymes and growth fac­tors are active com­po­nents in today´s inno­v­a­tive skin care cos­met­ics. Anti-micro­bial pep­tides and inno­v­a­tive sta­bi­liz­er serve as alter­na­tives to com­mon­ly used preser­v­a­tives which may cause irri­ta­tions or aller­genic reactions.

Pro­duc­tion process­es applied for man­u­fac­tur­ing of these new class of cos­met­ic ingre­di­ents need to address first of all safe­ty issues. At the same time, high vol­ume pro­duc­tion at con­sid­er­ably reduced man­u­fac­tur­ing costs is a pre­req­ui­site for suc­cess­ful mar­ket introduction.

ARTES´ Hansenu­la yeast tech­nol­o­gy pro­vides an excel­lent plat­form for large-scale, low-cost pro­duc­tion of cos­met­ic ingre­di­ents. Non-aller­genic and endo­tox­in free pro­duc­tion cell lines togeth­er with an antibi­ot­ic-resis­tance free vec­tor sys­tem form the basis for self-affirmed GRAS prod­ucts and safe cos­met­ic ingre­di­ents intro­duced in the market.

Biocatalysts

Phar­ma­ceu­ti­cals – Flavours – Fra­grances – Cos­met­ic Ingre­di­ents – Fine Chemicals

Whole-cell cat­a­lysts can act as high­ly spe­cif­ic, reusable tools in the man­u­fac­ture of var­i­ous fine chem­i­cals, phar­ma­ceu­ti­cals, fra­grances and cos­met­ic ingre­di­ents. Con­ver­sion of low cost sub­strate into high val­ue prod­uct can be real­ized in high­ly sus­tain­able process­es. While chem­i­cal reac­tions gen­er­al­ly result in con­se­quences such as pro­duc­tion of waste streams con­tain­ing var­i­ous tox­ic acids and heavy met­als and gen­er­a­tion of unde­sired by-prod­ucts, inno­v­a­tive process­es involv­ing yeast based whole-cell bio­cat­a­lysts gen­er­ate pure prod­uct at high effi­cien­cy and with­out unwant­ed, haz­ardous waste.

With ARTES´ yeast tech­nol­o­gy com­plex biosyn­thet­ic path­ways can be sta­bly imple­ment­ed and reusable bio­cat­a­lysts can be man­u­fac­tured at large scale and low costs.



Exam­ples of Hansenu­la based bio­cat­alyt­ic conversions:

  • pro­duc­tion of enan­tiomer­ic pure alco­hols (1‑S-phenylethanol, …
  • pro­duc­tion of pyru­vic acid and gly­oxylic acid
  • pro­duc­tion of Ectoin resp. Hydroxy-Ectoin as sub­stances in cosmetics
  • pro­duc­tion of cell-wall anchored enzymes; e.g. Can­di­da antarc­ti­ca Lipase B (CalB)