ARTES uses one of the most important industrial expression systems, the methylotrophic yeast Hansenula polymorpha. For our platform technology, we have all relevant IP rights as well as unpatent know-how. Our expertise is on trouble-shooting and project management. ARTES ensures 100% freedom-to-operate for all clients and licensees and guarantees a smooth and high standard project progress.

Features of Hansenula technology platform:

  • large toolbox (e.g. expression vectors, secretion signals, chaperones)
  • stable co-expression of multiple genes
  • high copy production cell lines with up to 120 genes per cell
  • 100% stability of production cell lines for so far > 25 years
  • absence of allergens, toxins and viral contaminations
  • secreted products without contaminating host cell proteins (> 90% purity in fermentation broth)
  • high yield production of intra-cellular soluble proteins
  • metabolic engineering for design of whole-cell biocatalysts
  • organism known at and recommended by a.o. US-FDA, EMA, EFSA and WHO
  • antibiotic resistance free host vector system