Cell Line Development

The focus of our tailor-made offer is on microbial production cell lines based on yeast (Hansenula, Pichia and Saccharomyces) and bacteria (E. coli). To meet customer’s demand,  ARTES Biotechnology develops the most efficient solution for the target of choice.

A transparent, well defined project design is agreed with our client prior to the start of the project, defining deliverables, timelines, milestones, Go/No-go decision points and costs.

A typical project starts with newly synthesized genes optimized for the respective host and providing a well defined origin for later registration. Within 6 – 8 weeks a first answer on feasibility of expression and protein localization is delivered and a mutual decision is taken on the progress of the cell line development. Next steps may include optimization of expression and/or secretion, generation of stable cell lines, selection of production cell line(s) for transfer to the client resp. for further process development at ARTES, genomic characterization and preliminary high cell density fermentation.