The focus of our tai­lor-made offer is on micro­bial pro­duc­tion cell lines based on yeast (Hansenu­la, Pichia and Sac­cha­romyces) and bac­te­ria (E. coli). To meet cus­tomer’s demand,  ARTES Biotech­nol­o­gy devel­ops the most effi­cient solu­tion for the tar­get of choice. 

A trans­par­ent, well defined project design is agreed with our client pri­or to the start of the project, defin­ing deliv­er­ables, time­lines, mile­stones, Go/No-go deci­sion points and costs.

A typ­i­cal project starts with new­ly syn­the­sized genes opti­mized for the respec­tive host and pro­vid­ing a well defined ori­gin for lat­er reg­is­tra­tion. With­in 6 – 8 weeks a first answer on fea­si­bil­i­ty of expres­sion and pro­tein local­iza­tion is deliv­ered and a mutu­al deci­sion is tak­en on the progress of the cell line devel­op­ment. Next steps may include opti­miza­tion of expres­sion and/or secre­tion, gen­er­a­tion of sta­ble cell lines, selec­tion of pro­duc­tion cell line(s) for trans­fer to the client resp. for fur­ther process devel­op­ment at ARTES, genom­ic char­ac­ter­i­za­tion and pre­lim­i­nary high cell den­si­ty fermentation.

ARTES‘ offer includes:

  • fea­si­bil­i­ty studies
  • pro­duc­tion cell line development
  • cell bank gen­er­a­tion, char­ac­ter­i­za­tion and transfer